Las Cruces may refer to:
- Battle of Monte de las Cruces
- Las Cruces, California
- Las Cruces, Chile
- Las Cruces, New Mexico (New Mexico's second-largest city)
- The main campus of New Mexico State University
- Las Cruces International Airport in New Mexico
- Las Cruces, Los Santos, Panama
- Las Cruces, Veraguas, Panama
- Las Cruces National Trail, Panama
- Las Cruces (band), doom metal band from San Antonio, Texas
- Las Cruces Biological Station, Costa Rica, one of the Organization for Tropical Studies (OTS) research stations
