Profit and Loss may refer to:
- Profit & Loss, monthly business magazine founded in July 1999 especializing in Foreign exchange market and derivative markets
- "Profit and Loss" (Star Trek: Deep Space Nine), the eighteenth episode of the second season of the television series Star Trek: Deep Space Nine
- Profit and loss statement, statement that indicates how net revenue is transformed into net income
- A synonym of net income
- Profit and the Loss, a British silent film
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